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KMID : 0379520010170010059
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한국독성학회지
2001 Volume.17 No. 1 p.59 ~ p.63
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Comparison of Skin Response Between New Zealand White Rabbit and Hartley Guinea Pig to Glycolic Acid
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Ahn Kwang-Soo
Jung Kyoung-Mi
Kim Yong-Kyu
Lee Jong-Kwon
Park Ki-Sook
Kim Eun-Joung
Lee Sun-Hee
Hong Jin-Tae
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Abstract
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In this study, we compared skin response between Hartley guinea pig and New Zealand white rabbit. New Zealand white rabbit was treated by a glycolic acid (0, 8, 24, 40, 56 mg/cm^2) and UVB (0, 0.4, 3.0 J/cm^2) for 14 days. Skin irritation by glycolic acid and UVB were increased in dose and time-dependent manners, and the combination treatment of UVB increased glycolic acid-induced skin irritation. Comparison the skin irritation index between guinea pig and rabbit showed that guinea pig was much more sensitive to glycolic acid and UVB. This study indicated that selection of reliable species of animal could be considered in chemical-induced skin irritation study.
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KEYWORD
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Skin irritation, Rabbit, Guinea Pig, Glycolic acid
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